The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

To survive proteotoxic stress, cancer cells activate the proteotoxic-stress response pathway, which is controlled by the transcription factor heat shock factor 1 (HSF1). This pathway supports cancer initiation, cancer progression and chemoresistance and thus is an attractive therapeutic target. As d...

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Publicat a:Cell Death Differ
Autors principals: Moreno, Rita, Banerjee, Sourav, Jackson, Angus W., Quinn, Jean, Baillie, Gregg, Dixon, Jack E., Dinkova-Kostova, Albena T., Edwards, Joanne, de la Vega, Laureano
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166837/
https://ncbi.nlm.nih.gov/pubmed/33268814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00686-8
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