Development of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying α-Synuclein–Containing Extracellular Vesicles

OBJECTIVE: To develop a reliable and fast assay to quantify the α-synuclein (α-syn)–containing extracellular vesicles (EVs) in CSF and to assess their diagnostic potential for Parkinson disease (PD). METHODS: A cross-sectional, multicenter study was designed, including 170 patients with PD and 131 h...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Hong, Zhen, Tian, Chen, Stewart, Tessandra, Aro, Patrick, Soltys, David, Bercow, Matt, Sheng, Lifu, Borden, Kayla, Khrisat, Tarek, Pan, Catherine, Zabetian, Cyrus P., Peskind, Elaine R., Quinn, Joseph F., Montine, Thomas J., Aasly, Jan, Shi, Min, Zhang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166433/
https://ncbi.nlm.nih.gov/pubmed/34032594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000011853
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