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Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms
L-type voltage-gated Ca(V)1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via protein kinase A (PKA)–induced increase of calcium influx through Ca(V)1.2 channels. To date, the full β-AR cascade has never been heterologously...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8166151/ https://ncbi.nlm.nih.gov/pubmed/34001616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100021118 |
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