Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms

L-type voltage-gated Ca(V)1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via protein kinase A (PKA)–induced increase of calcium influx through Ca(V)1.2 channels. To date, the full β-AR cascade has never been heterologously...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Katz, Moshe, Subramaniam, Suraj, Chomsky-Hecht, Orna, Tsemakhovich, Vladimir, Flockerzi, Veit, Klussmann, Enno, Hirsch, Joel A., Weiss, Sharon, Dascal, Nathan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166151/
https://ncbi.nlm.nih.gov/pubmed/34001616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100021118
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