Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders

Neovascularization is a key feature of ischemic retinal diseases and the wet form of age-related macular degeneration (AMD), all leading causes of severe vision loss. Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of these disorders. Millions of patients have bee...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Xin, Hong, Biswas, Nilima, Li, Pin, Zhong, Cuiling, Chan, Tamara C., Nudleman, Eric, Ferrara, Napoleone
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166142/
https://ncbi.nlm.nih.gov/pubmed/34006633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921252118
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