G-quadruplex structural variations in human genome associated with single-nucleotide variations and their impact on gene activity

G-quadruplexes (G4s) formed by guanine-rich nucleic acids play a role in essential biological processes such as transcription and replication. Besides the >1.5 million putative G-4–forming sequences (PQSs), the human genome features >640 million single-nucleotide variations (SNVs), the most co...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gong, Jia-yuan, Wen, Cui-jiao, Tang, Ming-liang, Duan, Rui-fang, Chen, Juan-nan, Zhang, Jia-yu, Zheng, Ke-wei, He, Yi-de, Hao, Yu-hua, Yu, Qun, Ren, Su-ping, Tan, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166059/
https://ncbi.nlm.nih.gov/pubmed/34001600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013230118
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