Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker

Liquorice is usually used as crude drug in traditional Japanese Kampo medicine and traditional Chinese medicine. Liquorice-containing glycyrrhizin (GL) can cause pseudohyperaldosteronism as a side effect. Previously, we identified 18β-glycyrrhetyl-3-O-sulfate (3) as a GL metabolite in Eisai hyperbil...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Ishiuchi, Kan'ichiro, Morinaga, Osamu, Yoshino, Tetsuhiro, Mitamura, Miaki, Hirasawa, Asuka, Maki, Yasuhito, Tashita, Yuuna, Kondo, Tsubasa, Ogawa, Kakuyou, Lian, Fangyi, Ogawa-Ochiai, Keiko, Minamizawa, Kiyoshi, Namiki, Takao, Mimura, Masaru, Watanabe, Kenji, Makino, Toshiaki
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8165744/
https://ncbi.nlm.nih.gov/pubmed/34079468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.688508
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