Amelioration of Beta Interferon Inhibition by NS4B Contributes to Attenuating Tembusu Virus Virulence in Ducks

Our previous studies reported that duck Tembusu virus nonstructural protein 2A (NS2A) is a major inhibitor of the IFNβ signaling pathway through competitively binding to STING with TBK1, leading to a reduction in TBK1 phosphorylation. Duck TMUV NS2B3 could cleave and bind STING to subvert the IFNβ s...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhang, Wei, Zeng, Miao, Jiang, Bowen, Lu, Tong, Guo, Jiaqi, Hu, Tao, Wang, Mingshu, Jia, Renyong, Zhu, Dekang, Liu, Mafeng, Zhao, Xinxin, Yang, Qiao, Wu, Ying, Zhang, Shaqiu, Ou, Xumin, Liu, Yunya, Zhang, Ling, Yu, Yanling, Pan, Leichang, Cheng, Anchun, Chen, Shun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8165282/
https://ncbi.nlm.nih.gov/pubmed/34079553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.671471
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