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Restoration of energy homeostasis by SIRT6 extends healthy lifespan
Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD(+)-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms that largely remain unknown. Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension i...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8163764/ https://ncbi.nlm.nih.gov/pubmed/34050173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23545-7 |
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