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Enthalpic and entropic contributions to the basicity of cycloalkylamines

Large-ring cycloalkylamines are slightly less basic than other cycloalkylamines such as cyclohexylamine, even though all have tetrahedral carbons and are strain-free. To understand why, enthalpy and entropy for protonation of a series of cycloalkylamines were accurately determined by isothermal titr...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Perrin, Charles L., Shrinidhi, Annadka
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163384/
https://ncbi.nlm.nih.gov/pubmed/34123109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc02931a
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