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Rhodium catalysed C-3/5 methylation of pyridines using temporary dearomatisation

Pyridines are ubiquitous aromatic rings used in organic chemistry and are crucial elements of the drug discovery process. Herein we describe a new catalytic method that directly introduces a methyl group onto the aromatic ring; this new reaction is related to hydrogen borrowing, and is notable for i...

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Vydáno v:Chem Sci
Hlavní autoři: Grozavu, Alexandru, Hepburn, Hamish B., Bailey, Elliot P., Lindsay-Scott, Peter J., Donohoe, Timothy J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163342/
https://ncbi.nlm.nih.gov/pubmed/34123119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc02759f
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