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Where are the disease-associated eQTLs?

Most disease-associated variants, although located in putatively regulatory regions, do not have detectable effects on gene expression. One explanation could be that we have not examined gene expression in the cell types or conditions that are most relevant for disease. Even large-scale efforts to s...

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Publicat a:Trends Genet
Autors principals: Umans, Benjamin D., Battle, Alexis, Gilad, Yoav
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162831/
https://ncbi.nlm.nih.gov/pubmed/32912663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2020.08.009
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