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Where are the disease-associated eQTLs?

Most disease-associated variants, although located in putatively regulatory regions, do not have detectable effects on gene expression. One explanation could be that we have not examined gene expression in the cell types or conditions that are most relevant for disease. Even large-scale efforts to s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Trends Genet
Prif Awduron: Umans, Benjamin D., Battle, Alexis, Gilad, Yoav
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162831/
https://ncbi.nlm.nih.gov/pubmed/32912663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2020.08.009
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