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Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein
In amyloid fibril elongation, soluble growth substrate binds to the fibril-end and converts into the fibril conformation. This process is targeted by inhibitors that block fibril-ends. Here, we investigated how the elongation of α-synuclein (αS) fibrils, which are associated with Parkinson's di...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8162328/ https://ncbi.nlm.nih.gov/pubmed/34094375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04051g |
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