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Asymmetric allylic substitution–isomerization to axially chiral enamides via hydrogen-bonding assisted central-to-axial chirality transfer

Axially chiral enamides bearing a N–C axis have been recently studied and were proposed to be valuable chiral building blocks, but a stereoselective synthesis has not been achieved. Here, we report the first enantioselective synthesis of axially chiral enamides via a highly efficient, catalytic appr...

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Vydáno v:Chem Sci
Hlavní autoři: Sun, Chao, Qi, Xiaotian, Min, Xiao-Long, Bai, Xue-Dan, Liu, Peng, He, Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162293/
https://ncbi.nlm.nih.gov/pubmed/34094274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc02828b
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