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Synthetic studies toward longeracemine: a SmI(2)-mediated spirocyclization and rearrangement cascade to construct the 2-azabicyclo[2.2.1]heptane framework

Longeracemine, a member of the Daphniphyllum family of alkaloids contains a novel carbon framework featuring a highly functionalized 2-azabicyclo[2.2.1]heptane core as part of an overall 5/6/5/5/6/5 skeleton. A synthetic intermediate containing the core of longeracemine has been efficiently prepared...

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Publicat a:Chem Sci
Autors principals: Komine, Keita, Lambert, Kyle M., Savage, Quentin R., Cox, Joshua B., Wood, John L.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society of Chemistry 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162136/
https://ncbi.nlm.nih.gov/pubmed/34094215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03422c
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