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Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

We present a near-term treatment strategy to tackle pandemic outbreaks of coronaviruses with no specific drugs/vaccines by combining evolutionary and physical principles to identify conserved viral domains containing druggable Zn-sites that can be targeted by clinically safe Zn-ejecting compounds. B...

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Foilsithe in:Chem Sci
Main Authors: Sargsyan, Karen, Lin, Chien-Chu, Chen, Ting, Grauffel, Cédric, Chen, Yi-Ping, Yang, Wei-Zen, Yuan, Hanna S., Lim, Carmay
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Royal Society of Chemistry 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162115/
https://ncbi.nlm.nih.gov/pubmed/34094251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc02646h
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