Simvastatin Reduces Fetal Testosterone Production and Permanently Alters Reproductive Tract Development in the Crl:CD(SD) Male Rat

We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowered circulating lipids and testicular testosterone production in Hsd:SD (Harlan Sprague Dawley) fetal males and reduced testosterone in an additive manner when co-administere...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Beverly, Brandiese E.J., Furr, Johnathan R., Lambright, Christy S., Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M.D., Travlos, Greg, Gray, L. Earl
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161526/
https://ncbi.nlm.nih.gov/pubmed/30639414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.01.001
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