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Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice

Three major cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, mediate endotoxemia-induced liver injury. With the similar structures to the binding domains of the three cytokines to their cognate receptors, the novel peptide KCF18 can simultaneously inhibit TNF-α...

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Detalhes bibliográficos
Publicado no:J Pers Med
Main Authors: Shih, Hung-Jen, Chang, Chao-Yuan, Chiang, Milton, Le, Van Long, Hsu, Hao-Jen, Huang, Chun-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161041/
https://ncbi.nlm.nih.gov/pubmed/34065201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm11050436
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