Structures of Chaperone-Associated Assembly Intermediates Reveal Coordinated Mechanisms of Proteasome Biogenesis

The proteasome mediates most selective protein degradation. Proteolysis occurs within the 20S core particle (CP), a barrel-shaped chamber with an α(7)β(7)β(7)α(7) configuration. CP biogenesis proceeds through an ordered multistep pathway requiring five chaperones, Pba1–4 and Ump1. Using S. cerevisia...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Schnell, Helena M., Walsh, Richard M., Rawson, Shaun, Kaur, Mandeep, Bhanu, Meera K., Tian, Geng, Prado, Miguel A., Guerra-Moreno, Angel, Paulo, Joao A., Gygi, Steven P., Roelofs, Jeroen, Finley, Daniel, Hanna, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160580/
https://ncbi.nlm.nih.gov/pubmed/33846632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-021-00583-9
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