Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection

In response to infection, pathogen-specific CD8 T cells differentiate into functionally diverse effector and memory T cell populations critical for resolving disease and providing durable immunity. Through small-molecule inhibition, RNAi studies, and induced genetic deletion, we reveal an essential...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Milner, J. Justin, Toma, Clara, Quon, Sara, Omilusik, Kyla, Scharping, Nicole E., Dey, Anup, Reina-Campos, Miguel, Nguyen, Hongtuyet, Getzler, Adam J., Diao, Huitian, Yu, Bingfei, Delpoux, Arnaud, Yoshida, Tomomi M., Li, Deyao, Qi, Jun, Vincek, Adam, Hedrick, Stephen M., Egawa, Takeshi, Zhou, Ming-Ming, Crotty, Shane, Ozato, Keiko, Pipkin, Matthew E., Goldrath, Ananda W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2021
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160575/
https://ncbi.nlm.nih.gov/pubmed/34037670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202512
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