Nuclear m(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

N(6)-methyladenosine (m(6)A) on chromosome-associated regulatory RNAs (carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and transcription, but the intrinsic mechanism remains unclear. Here, we report that YTHDC1 plays indispensable roles in the self-renewal and di...

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Pubblicato in:Protein Cell
Autori principali: Chen, Chuan, Liu, Wenqiang, Guo, Jiayin, Liu, Yuanyuan, Liu, Xuelian, Liu, Jun, Dou, Xiaoyang, Le, Rongrong, Huang, Yixin, Li, Chong, Yang, Lingyue, Kou, Xiaochen, Zhao, Yanhong, Wu, You, Chen, Jiayu, Wang, Hong, Shen, Bin, Gao, Yawei, Gao, Shaorong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Higher Education Press 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160034/
https://ncbi.nlm.nih.gov/pubmed/33886094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-021-00837-8
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