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Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility
OBJECTIVE: Humans and mice with loss-of-function variants of genes in the transforming growth factor beta (TGF-β) signaling pathway develop aortic aneurysms. These aneurysms could be caused by decreased aortic smooth muscle cell (SMC) contractile-protein levels and impaired aortic SMC contractile-un...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8159907/ https://ncbi.nlm.nih.gov/pubmed/33853348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.121.315878 |
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