Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Dysregulated protein degradative pathways are increasingly recognized as mediators of human disease. This mechanism may have particular relevance to desmosomal proteins that play critical structural roles in both tissue architecture and cell-cell communication, as destabilization/breakdown of the de...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liang, Yan, Lyon, Robert C., Pellman, Jason, Bradford, William H., Lange, Stephan, Bogomolovas, Julius, Dalton, Nancy D., Gu, Yusu, Bobar, Marcus, Lee, Mong-Hong, Iwakuma, Tomoo, Nigam, Vishal, Asimaki, Angeliki, Scheinman, Melvin, Peterson, Kirk L., Sheikh, Farah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159691/
https://ncbi.nlm.nih.gov/pubmed/33857019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137689
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