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Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

The enzymes glucose oxidase (GOx), acetylcholine esterase (AchE) and urease that drive biocatalytic transformations to alter pH, are integrated into pH-responsive DNA-based hydrogels. A two-enzyme-loaded hydrogel composed of GOx/urease or AchE/urease and a three-enzyme-loaded hydrogel composed of GO...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Wang, Chen, Fischer, Amit, Ehrlich, Avner, Nahmias, Yaakov, Willner, Itamar
Format: Artigo
Language:Inglês
Published: The Royal Society of Chemistry 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159436/
https://ncbi.nlm.nih.gov/pubmed/34122910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01319f
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