Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons’ Degeneration: Link to Parkinson’s Disease

Rhes is one of the most interesting genes regulated by thyroid hormones that, through the inhibition of the striatal cAMP/PKA pathway, acts as a modulator of dopamine neurotransmission. Rhes mRNA is expressed at high levels in the dorsal striatum, with a medial-to-lateral expression gradient reflect...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Serra, Marcello, Pinna, Annalisa, Costa, Giulia, Usiello, Alessandro, Pasqualetti, Massimo, Avallone, Luigi, Morelli, Micaela, Napolitano, Francesco
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158741/
https://ncbi.nlm.nih.gov/pubmed/34070217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105326
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