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Computational Investigation Identified Potential Chemical Scaffolds for Heparanase as Anticancer Therapeutics
Heparanase (Hpse) is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains. Its upregulated expression is implicated in tumor growth, metastasis and angiogenesis, thus making it an attractive target in cancer therapeutics. Currently, a few small molecule inhibitors have been repo...
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| Yayımlandı: | Int J Mol Sci |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
MDPI
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8157885/ https://ncbi.nlm.nih.gov/pubmed/34156395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105311 |
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