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3-Bromotetrazine: labelling of macromolecules via monosubstituted bifunctional s-tetrazines

We report the synthesis and first characterisation of the novel chemical probe 3-bromotetrazine and establish its reactivity towards nucleophiles. This led to the synthesis of several novel classes of 3-monosubstituted s-tetrazines. A remarkable functional group selectivity is observed and is utilis...

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Publicado en:Chem Sci
Main Authors: Schnell, Simon D., Hoff, Lukas V., Panchagnula, Advaita, Wurzenberger, Maximilian H. H., Klapötke, Thomas M., Sieber, Simon, Linden, Anthony, Gademann, Karl
Formato: Artigo
Idioma:Inglês
Publicado: The Royal Society of Chemistry 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157750/
https://ncbi.nlm.nih.gov/pubmed/34122808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc06169j
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