A Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies

PURPOSE: Although strongly related, the pathophysiological effect of the N34S mutation in the serine protease inhibitor Kazal type 1 (SPINK1) in chronic pancreatitis is still unknown. In this study, we investigate the conformational space of the human cationic trypsin-serine protease inhibitor compl...

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Publicado en:J Inflamm Res
Autores principales: Kulke, Martin, Nagel, Felix, Schulig, Lukas, Geist, Norman, Gabor, Marcel, Mayerle, Julia, M Lerch, Markus, Link, Andreas, Delcea, Mihaela
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove 2021
Materias:
Hypothesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157096/
https://ncbi.nlm.nih.gov/pubmed/34054303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S304787
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