Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice

Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes. In the genetic, iron-loading disorder hereditary hemochromatosis (HH), hepcidin...

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Detalhes bibliográficos
Publicado no:Nutrients
Main Authors: Wang, Xiaoyu, Zhang, Mingzhen, Woloshun, Regina R., Yu, Yang, Lee, Jennifer K., Flores, Shireen R. L., Merlin, Didier, Collins, James F.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157040/
https://ncbi.nlm.nih.gov/pubmed/34063414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu13051686
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