Sildenafil Alleviates Murine Experimental Autoimmune Encephalomyelitis by Triggering Autophagy in the Spinal Cord

Multiple Sclerosis (MS) is a neuroinflammatory and chronic Central Nervous System (CNS) disease that affects millions of people worldwide. The search for more promising drugs for the treatment of MS has led to studies on Sildenafil, a phosphodiesterase type 5 Inhibitor (PDE5I) that has been shown to...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Duarte-Silva, Eduardo, Meiry da Rocha Araújo, Shyrlene, Oliveira, Wilma Helena, Lós, Deniele Bezerra, Bonfanti, Amanda Pires, Peron, Gabriela, de Lima Thomaz, Livia, Verinaud, Liana, Peixoto, Christina Alves
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156813/
https://ncbi.nlm.nih.gov/pubmed/34054847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.671511
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