Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved pharmacokinetics promoted by gated MSNs. The system consists of the transfection of c...

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Bibliographic Details
Published in:Nanomaterials (Basel)
Main Authors: Candela-Noguera, Vicente, Vivo-Llorca, Gema, Díaz de Greñu, Borja, Alfonso, María, Aznar, Elena, Orzáez, Mar, Marcos, María Dolores, Sancenón, Félix, Martínez-Máñez, Ramón
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156333/
https://ncbi.nlm.nih.gov/pubmed/34069171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nano11051298
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