Amide–Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility

[Image: see text] Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide–amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10–20-fold) improvements in solubility. P...

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Publicat a:ACS Med Chem Lett
Autors principals: Tan, Yu Jia, Li, Ming, Gunawan, Gregory Adrian, Nyantakyi, Samuel Agyei, Dick, Thomas, Go, Mei-Lin, Lam, Yulin
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155280/
https://ncbi.nlm.nih.gov/pubmed/34055215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00588
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