Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression

Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we exami...

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Publicado no:Nat Commun
Main Authors: Cooper, Jessica A., Nuutinen, Makiah R., Lawlor, Victoria M., DeVries, Brittany A. M., Barrick, Elyssa M., Hossein, Shabnam, Cole, Daniel J., Leonard, Chelsea V., Hahn, Evan C., Teer, Andrew P., Shields, Grant S., Slavich, George M., Ongur, Dost, Jensen, J. Eric, Du, Fei, Pizzagalli, Diego A., Treadway, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155144/
https://ncbi.nlm.nih.gov/pubmed/34039978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23284-9
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