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GRiNCH: simultaneous smoothing and detection of topological units of genome organization from sparse chromatin contact count matrices with matrix factorization

High-throughput chromosome conformation capture assays, such as Hi-C, have shown that the genome is organized into organizational units such as topologically associating domains (TADs), which can impact gene regulatory processes. The sparsity of Hi-C matrices poses a challenge for reliable detection...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Lee, Da-Inn, Roy, Sushmita
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152090/
https://ncbi.nlm.nih.gov/pubmed/34034791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02378-z
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