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Creating a ‘Molecular Band-Aid’; Blocking an Exposed Protease Target Site in Desmoplakin
Desmoplakin (DSP) is a large (~260 kDa) protein found in the desmosome, a subcellular complex that links the cytoskeleton of one cell to its neighbor. A mutation ‘hot-spot’ within the NH(2)-terminal third of the DSP protein (specifically, residues 299–515) is associated with both cardiomyopathies an...
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| Publicado no: | J Pers Med |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8151963/ https://ncbi.nlm.nih.gov/pubmed/34065787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jpm11050401 |
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