Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice

Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful for pre-clinical investigations in mouse models of disease....

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Kerr, Heather, Herbert, Andrew P., Makou, Elisavet, Abramczyk, Dariusz, Malik, Talat H., Lomax-Browne, Hannah, Yang, Yi, Pappworth, Isabel Y., Denton, Harriet, Richards, Anna, Marchbank, Kevin J., Pickering, Matthew C., Barlow, Paul N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149785/
https://ncbi.nlm.nih.gov/pubmed/34054871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.681098
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