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Efficacy, safety and tolerability of drugs studied in phase 3 randomized controlled trials in solid tumors over the last decade

Data suggest that for newly approved cancer drugs safety and tolerability are worse than in control arms of registration trials. Less is known about the balance between efficacy and toxicity of drugs studied in unselected phase 3 randomized controlled trials (RCTs) including those not resulting in r...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ribnikar, Domen, Goldvaser, Hadar, Veitch, Zachary W., Ocana, Alberto, Templeton, Arnoud J., Šeruga, Boštjan, Amir, Eitan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149406/
https://ncbi.nlm.nih.gov/pubmed/34035370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90403-3
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