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5-Aza-2′-deoxycytidine reactivates the CDH1 gene without influencing methylation of the entire CpG island or histone modification in a human cancer cell line

It is well-recognized that DNA methylation and histone modifications play critical roles in epigenetic regulation of gene activity through the alteration of chromatin structure. Recent studies have shown that in a subset of cancer cells, the silencing of the human E-cadherin (CDH1) gene is associate...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Jpn Acad Ser B Phys Biol Sci
Prif Awduron: Tachibana, Ken, Takeda, Ken, Shiraishi, Masahiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Japan Academy 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147665/
Tagiau: Ychwanegu Tag
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