Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer

Heat shock protein 27 (Hsp27) has an established role in tumor progression and chemo-resistance of castration-resistant prostate cancer (CRPC). Hsp27 protects eukaryotic translation initiation factor 4E (eIF4E) from degradation, thereby maintaining survival during treatment. Phenazine derivative com...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Ziouziou, Hajer, Paris, Clément, Benizri, Sébastien, Le, Thi Khanh, Andrieu, Claudia, Nguyen, Dang Tan, Appavoo, Ananda, Taïeb, David, Brunel, Frédéric, Oueslati, Ridha, Siri, Olivier, Camplo, Michel, Barthélémy, Philippe, Rocchi, Palma
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146835/
https://ncbi.nlm.nih.gov/pubmed/33925528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13050623
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