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Supercritical CO(2) Extraction of Organic Solvents from Flunisolide and Fluticasone Propionate

In this work, Class 2 and Class 3 solvents contained in two corticosteroids, flunisolide (Fluni) and fluticasone propionate (Fluti), were reduced to a few ppm by supercritical CO(2) extraction. The process was carried out at pressures from 80 to 200 bar, temperatures of 40 °C and 80 °C, and at a fix...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutics
Hauptverfasser: Baldino, Lucia, Scognamiglio, Mariarosa, Reverchon, Ernesto
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146547/
https://ncbi.nlm.nih.gov/pubmed/33922659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13050612
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