Up-Regulation of Immune Checkpoints in the Thymus of PRRSV-1-Infected Piglets in a Virulence-Dependent Fashion

Virulent porcine reproductive and respiratory syndrome virus (PRRSV) strains, such as the Lena strain, have demonstrated a higher thymus tropism than low virulent strains. Virulent PRRSV strains lead to severe thymus atrophy, which could be related to marked immune dysregulation. Impairment of T-cel...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Ruedas-Torres, Inés, Rodríguez-Gómez, Irene M., Sánchez-Carvajal, José María, Guil-Luna, Silvia, Larenas-Muñoz, Fernanda, Pallarés, Francisco J., Carrasco, Librado, Gómez-Laguna, Jaime
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144631/
https://ncbi.nlm.nih.gov/pubmed/34046040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.671743
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