A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin(2α)-induced corpus luteum regression

Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis. The apoptotic function of RIPK3 requires phosphorylation of the ser...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Li, Dianrong, Chen, Jie, Guo, Jia, Li, Lin, Cai, Gaihong, Chen, She, Huang, Jia, Yang, Hui, Zhuang, Yinhua, Wang, Fengchao, Wang, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143796/
https://ncbi.nlm.nih.gov/pubmed/34029184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67409
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