Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background

Down syndrome critical region (DSCR)-1 functions as a feedback modulator for calcineurin-nuclear factor for activated T cell (NFAT) signals, which are crucial for cell proliferation and inflammation. Stable expression of DSCR-1 inhibits pathological angiogenesis and septic inflammation. DSCR-1 also...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Muramatsu, Masashi, Osawa, Tsuyoshi, Miyamura, Yuri, Nakagawa, Suguru, Tanaka, Toshiya, Kodama, Tatsuhiko, Aburatani, Hiroyuki, Sakai, Juro, Ryeom, Sandra, Minami, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8142255/
https://ncbi.nlm.nih.gov/pubmed/33895138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100697
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