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Oxidation of peroxiredoxin-4 induces oligomerization and promotes interaction with proteins governing protein folding and endoplasmic reticulum stress
Peroxiredoxins (PRDXs) catalyze the reduction of hydrogen peroxide (H(2)O(2)). PRDX4 is the only peroxiredoxin located within the endoplasmic reticulum (ER) and is the most highly expressed H(2)O(2) scavenger in the ER. PRDX4 has emerged as an important player in numerous diseases, such as fibrosis...
Gespeichert in:
| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8141880/ https://ncbi.nlm.nih.gov/pubmed/33895140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100665 |
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