Oxidation of peroxiredoxin-4 induces oligomerization and promotes interaction with proteins governing protein folding and endoplasmic reticulum stress

Peroxiredoxins (PRDXs) catalyze the reduction of hydrogen peroxide (H(2)O(2)). PRDX4 is the only peroxiredoxin located within the endoplasmic reticulum (ER) and is the most highly expressed H(2)O(2) scavenger in the ER. PRDX4 has emerged as an important player in numerous diseases, such as fibrosis...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Elko, Evan A., Manuel, Allison M., White, Sheryl, Zito, Ester, van der Vliet, Albert, Anathy, Vikas, Janssen-Heininger, Yvonne M.W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141880/
https://ncbi.nlm.nih.gov/pubmed/33895140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100665
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