Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2

Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we employ a preclinical model to identify the therapeutic targets of VPA. We find compounds that inhibit histone deacetylase proteins (HDACs) are ef...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Logan, Ryan W., Ozburn, Angela R., Arey, Rachel N., Ketchesin, Kyle D., Winquist, Alicia, Crain, Andrew, Tobe, Brian T. D., Becker-Krail, Darius, Jarpe, Matthew B., Xue, Xiangning, Zong, Wei, Huo, Zhiguang, Parekh, Puja K., Zhu, Xiyu, Fitzgerald, Ethan, Zhang, Hui, Oliver-Smith, Jeffrey, DePoy, Lauren M., Hildebrand, Mariah A., Snyder, Evan Y., Tseng, George C., McClung, Colleen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141541/
https://ncbi.nlm.nih.gov/pubmed/33235333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-00958-2
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