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The PRRA Insert at the S1/S2 Site Modulates Cellular Tropism of SARS-CoV-2 and ACE2 Usage by the Closely Related Bat RaTG13
Biochemical and structural analyses suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) efficiently infects humans, and the presence of four residues (PRRA) at the S1/S2 site within the spike (S) protein may lead to unexpected tissue or host tropism. Here, we report that SARS-C...
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| Publicado no: | J Virol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8139715/ https://ncbi.nlm.nih.gov/pubmed/33685917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01751-20 |
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