People with HIV-1 Demonstrate Type 1 Interferon Refractoriness Associated with Upregulated USP18

HIV-1 infection persists in humans despite expression of antiviral type 1 interferons (IFN). Even exogenous administration of IFNα only marginally reduces HIV-1 abundance, raising the hypothesis that people living with HIV-1 (PLWH) are refractory to type 1 IFN. We demonstrated type 1 IFN refractorin...

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Vydáno v:J Virol
Hlavní autoři: Sugawara, Sho, El-Diwany, Ramy, Cohen, Laura K., Rousseau, Kimberly E., Williams, Christopher Y. K., Veenhuis, Rebecca T., Mehta, Shruti H., Blankson, Joel N., Thomas, David L., Cox, Andrea L., Balagopal, Ashwin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139647/
https://ncbi.nlm.nih.gov/pubmed/33658340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01777-20
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