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Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation

BACKGROUND: Tofacitinib is a novel Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. In clinical trials, the most common adverse events observed were nasopharyngitis, upper respiratory tract infections, and zoster. JAKs are...

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Bibliografiset tiedot
Julkaisussa:Arthritis Res Ther
Päätekijät: Hawerkamp, Heike C., Domdey, Alina, Radau, Lisa, Sewerin, Philipp, Oláh, Péter, Homey, Bernhard, Meller, Stephan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138978/
https://ncbi.nlm.nih.gov/pubmed/34020693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02509-8
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