Dissociation of the G protein βγ from the Gq–PLCβ complex partially attenuates PIP2 hydrolysis

Phospholipase C β (PLCβ), which is activated by the Gq family of heterotrimeric G proteins, hydrolyzes the inner membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), generating diacylglycerol and inositol 1,4,5-triphosphate (IP3). Because Gq and PLCβ regulate many crucial cellular processes...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Kankanamge, Dinesh, Ubeysinghe, Sithurandi, Tennakoon, Mithila, Pantula, Priyanka Devi, Mitra, Kishalay, Giri, Lopamudra, Karunarathne, Ajith
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138763/
https://ncbi.nlm.nih.gov/pubmed/33901492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100702
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