Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals a non-canonical open conformation

The eukaryotic signal recognition particle (SRP) contains an Alu domain, which docks into the factor binding site of translating ribosomes and confers translation retardation. The canonical Alu domain consists of the SRP9/14 protein heterodimer and a tRNA-like folded Alu RNA that adopts a strictly ‘...

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Udgivet i:Commun Biol
Main Authors: Soni, Komal, Kempf, Georg, Manalastas-Cantos, Karen, Hendricks, Astrid, Flemming, Dirk, Guizetti, Julien, Simon, Bernd, Frischknecht, Friedrich, Svergun, Dmitri I., Wild, Klemens, Sinning, Irmgard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137916/
https://ncbi.nlm.nih.gov/pubmed/34017052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02132-y
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