TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma

Glioblastoma (GBM) remains an aggressive brain tumor with a high rate of mortality. Immune checkpoint (IC) molecules are expressed on tumor infiltrating lymphocytes (TILs) and promote T cell exhaustion upon binding to IC ligands expressed by the tumor cells. Interfering with IC pathways with immunot...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Raphael, Itay, Kumar, Rajeev, McCarl, Lauren H., Shoger, Karsen, Wang, Lin, Sandlesh, Poorva, Sneiderman, Chaim T., Allen, Jordan, Zhai, Shuyan, Campagna, Marissa Lynn, Foster, Alexandra, Bruno, Tullia C., Agnihotri, Sameer, Hu, Baoli, Castro, Brandyn A., Lieberman, Frank S., Broniscer, Alberto, Diaz, Aaron A., Amankulor, Nduka M., Rajasundaram, Dhivyaa, Pollack, Ian F., Kohanbash, Gary
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137816/
https://ncbi.nlm.nih.gov/pubmed/34025646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.637146
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